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Varying Malaria Rapid Diagnostic Test Accuracy by Regional Transmission Level and Demographics in Tanzania
Submitted by: Misago Seth
Version: 1.0
Year: 2025
10.1101/2025.07.17.25331734
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Description
Malaria remains a significant global health burden, with approximately 263 million cases across 83 countries. It's essential for malarial infection control to quickly and accurately detect cases. Given the widespread use of malaria rapid diagnostic testing (mRDTs) for case management and surveillance, it's essential to understand test reliability. Clarifying how mRDT results differ from qPCR results, and the nature of additional variance by test manufacturer, will be useful for reducing measurement bias. In comparing 3 national standard mRDTs and a research mRDT with qPCR results from a 2021 cross-sectional study in Tanzania, differences were found by age, gender and regional malaria transmission rate. The research test overall underperformed, with poor sensitivity across transmission strata. In comparing the research mRDT to standard mRDTs, odds ratios suggested transmission intensity may affect mRDT agreement and diagnostic performance. These results offer pertinent information on test accuracy and decrease outcome misclassification for malaria prevalence.
Creators / Authors
Danielle Wiener
- University of North Carolina at Chapel Hill
Misago D. Seth
- National Institute for Medical Research
Celine I. Mandara
- National Institute for Medical Research
Rashid A. Madebe
- National Institute for Medical Research
Zachary R. Popkin-Hall
- University of North Carolina at Chapel Hill
David Giesbrecht
- Brown University
Catherine Bakari
- National Institute for Medical Research
Beatus Lyimo
- National Institute for Medical Research
Dativa Pereus
- Muhimbili University of Health and Allied Sciences
Filbert Francis
- National Institute for Medical Research
Daniel Mbwambo
- African Malaria Network Trust
Sijenunu Aaron
- African Malaria Network Trust
Abdalah Lusasi
- African Malaria Network Trust
Samwel Lazaro
- African Malaria Network Trust
Timothy P. Sheahan
- University of North Carolina at Chapel Hill
Jonathan B. Parr
- University of North Carolina at Chapel Hill
Jeffrey A. Bailey
- Brown University
Deus S. Ishengoma
- National Institute for Medical Research
Jonathan J. Juliano
- University of North Carolina at Chapel Hill
Publication Details
Journal/Conference
medRxiv
Type
Other
Peer Review
Unknown
Project
N/A
Publisher
medRxiv
Resource Category
Publication
Language
en
Visibility
public
Status
published
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